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In any case, both strains we call sativa and the strains we call indicacan be useful for depression. Energetic and euphoric Sativa strains can help with motivation, anhedonia, and fatigue symptoms. Relaxing and sleepy indica strains can help with restlessness, stress, and insomnia. Both Sativa and Indica can be used to treat depression and anxiety, but they have different effects. Sativa is more energizing and uplifting, while Indica is more relaxing and sedating. If you are unsure which one to use, talk to your doctor or a Cannabis specialist. It is generally accepted that for the treatment of anxiety and depression, it is best to use substances with a high content of CBD, that is, cannabis indica. It does not have a psychotropic effect on the mind, but it relaxes and reduces the level of accumulated stress.